An advanced physiological data logger for medical imaging applications

  • Tareq Hasan Khan1 and

    Affiliated with

    • Khan A Wahid1Email author

      Affiliated with

      EURASIP Journal on Embedded Systems20122012:10

      DOI: 10.1186/1687-3963-2012-10

      Received: 8 August 2012

      Accepted: 20 November 2012

      Published: 26 December 2012


      The interest of physiological data sensing and recording using wireless body sensor network has increased in recent years due to the advancement of miniature and portable electronic devices. In this study, the design of a portable and rechargeable data logger with high data rate multiple wireless connectivity (Bluetooth and 2.4-GHz radio frequency) is discussed. The data are logged in micro secure digital (SD) cards and can be transferred to PC or Smartphone using SD card reader, USB interface, or Bluetooth wireless link. Analog signals can also be logged through an 8-channel analog-to-digital interface. A graphical LCD with touch screen is added for control and diagnosis. The hardware is generic and targeted for various medical imaging and data collection applications. The functionality of the prototype is later tested for wireless capsule endoscopy and skin temperature logging application.


      Data logger Bluetooth Wireless link Capsule endoscopy Analog-to-digital


      Recent advances in miniature and portable bio-sensors, embedded processors, and wireless technologies have caused a rapid growth in sensing and recording physiological signals for medical applications. Bio-sensors convert body signals such as temperature, blood pressure, breathing [1], heartbeat [24], etc., to electrical signals to be processed, transmitted, and recorded in electronic devices [5]. Data coming from implanted or external body sensors can be transmitted wirelessly to a portable and wearable data logger unit, thus giving the patient the freedom to do household works during continuous data recording without the hassle of cumbersome wired devices. After logging is completed, the data are transferred to a personal computer (PC) or Smartphone which may be later examined by physicians. In this article, a portable, battery-operated data logger unit having wireless connectivity with the bio-sensor is discussed. The design of the data logger is general and can be used for several medical applications. In this article, the prototype is demonstrated for video wireless capsule endoscopy (WCE) [6] and skin temperature logging application.

      Several works are found in the literature related to data logging for medical applications. In [7], a data logger unit for storing galvanic skin response for autistic patients is discussed. The data logger receives data using RS232 interface and stores it in a 16-MB EEPROM. In [2], the design of a data logger is discussed for electrocardiogram (ECG) signals. The design converts the analog ECG signals to digital and stores them in 20-MB flash memory cards. An ECG signal data logger with custom-designed ASIC controller for multimedia card (MMC) is discussed in [3]. In [8], a fetal and maternal heart beat signal recorder is discussed which detects signals using skin electrodes, converts them to digital, and stores in temporary SRAM for later transfer to PC by RS232 interface. A portable data logger with three body-fixed inertial sensors for monitoring the physical activities of Parkinson’s disease patients is proposed in [9]. In [10], the design of a microcontroller-based portable data logger for medical application is described which contains three-electrode ECG circuit, three accelerometers, a pressure sensor, and a temperature sensor. The module can store data in 4-Mb flash memory in real-time or can send data to PC by a wired serial interface. A low power and small size design of an ECG signal recorder is described in [11] for the purpose of long-term portable recording. Data are stored in secure digital (SD) card and can be transferred to PC by an isolated RS232 interface. In [12], fetal movements are recorded continuously on several pregnant patients using fetal movement acceleration measurement recorder to study its suitability in long-term home monitoring application. The work in [13] presents an IP core for FPGA-based ECG data transmission using wired telephone line through modem interface. Note that, the above-discussed data loggers receive data from body sensors using wired connections which is not comfortable for patients. In [14], a microcontroller-based data logger is implemented by using a four-channel analog-to-digital converter (ADC) to measure sweat activity. Data are stored in an EEPROM with the capability of storing data for over 2 days when one measurement is taken per minute. An RF transceiver is used to export the data to a monitoring host PC. A wireless data logger for recording human movements is discussed in [15]; however, the data logger is not portable as it takes power from house AC line supply, thus restricts the patient’s movement near to the data logger. In [16], an ARM microcontroller-based wearable heart rate monitor system is described. It gathers ECE data and sends the data to a nearby PC wirelessly using Bluetooth. It does not have internal storage memory and thus the patient’s movements are restricted near the host PC. In [17], a Java2-based software for cell phone is developed to store laboratory data, such as blood pressure, blood urea nitrogen, creatinine, Hb A1c (glycosylated hemoglobin), and other pertinent comments, into a cell phone memory. However, the cell phone does not have any sensor connected with it for automatic data acquisition.

      The data logger presented in this study is portable and has high data rate of 2 Mbps wireless connectivity with implantable or externally attached body sensors which eliminated the need for wires. It also has high memory capacity of 4 GB micro SD card, graphical display for showing images, graphs, charts in real time, keypad, and touch screen-based user interface. After logging, the data can be transferred to PC using an SD card reader at a speed of up to 25 MB/s or using an USB interface. Optionally, the data can also be transferred to PC or Smartphone wirelessly using Bluetooth technology. An illustration of a data logging system of a wireless body sensor system using the proposed data logger is shown in Figure 1.
      Figure 1

      Illustration of a wireless body sensor data logging system.

      Design requirements

      In order to make an advanced data logger that is useful to various medical image and video application, we consider the following design requirements.

      •  The data logger must have both wired and wireless input connectivity so that it can be connected with various in-body sensors. For example, for accelerometer or heart monitoring system, it uses wired analog interface, whereas for applications like WCE, it uses wireless RF interface.

      •  The data logger must have high storage capacity for data intensive application. For example, in WCE, to store QVGA (320 × 240) color, 24 bits-per-pixel images transmitted at 2 frames-per-second (FPS) having 80% compression ratio (CR) for 10 h, at least 3.1 GB memory space is required as calculated using (1).
        Store capacity = Width × Height × Bits Per Pixel × 1 CR × FPS × Logging time in hour × 3600
      •  The logger must consume low power so that the battery runs for longer time. For example, in WCE, it must run continuously for at least 10 h.

      •  The data rate of the wireless transceiver and the writing speed of the data logger must be high enough to support storing color video. For example, for QVGA resolution at 2 FPS and 80% CR, the required data rate of the wireless transceiver is at least 720 kbps. The writing speed in storage memory must be higher than 90 kB/s in this case.

      •  The data logger should be able to communicate with the bio-sensor in real-time during logging and control various features of the sensor, such as, changing image resolution, data rate, data types, etc. The interface used for this interactive control operation must be easy to use.

      •  Real-time viewing (RTV) of the data (i.e., images, charts, etc.) is another important feature. It will assist a physician performing diagnosis in real-time.

      •  After data logging is completed, there must be easy and fast way to transfer the data to workstation PC or Smartphone for diagnostics. As a result, we propose to have multiple wired and wireless output (or transfer) connectivity such as, USB interface, micro SD, and Bluetooth.

      •  To be wearable and easily portable, the physical size and weight of the data logger must be as less as possible.


      The data logger is designed to have four layers as shown in Figure 2. Each layer completes its functionality by using the resources of its lower layers. By only changing the application layer firmware, the data logger can be used in several applications, without modifying the lower level driver and hardware layers. A brief description of each layer is given in the following sections.
      Figure 2

      Data logger design layers.


      The overall block diagram of the hardware is shown in Figure 3. The design consists of a microcontroller (MCU) and several peripherals connected with it. Each major component of the design is briefly described below.
      Figure 3

      Block diagram of the data logger hardware.


      A microcontroller from the XMEGA-A1 [18] family is chosen for this design. A comparison of XMEGA with other microcontrollers is given in Table 1. To increase the data sample rate and writing speed in the storage device, a high-speed MCU is required. Moreover, several peripherals are connected with the MCU using SPI and USART protocols. The XMEGA microcontroller has more hardware SPI and USART units than others which is an advantage. It has 78 programmable I/O lines, 128-kB flash for program storage, 8-kB SRAM, and 2-kB EEPROM to store user defined variables temporarily and permanently namely.
      Table 1

      Comparison of several MCU


      Clock (MHz)

      SRAM (kB)

      Hardware SPI

      Hardware USART

      Core power (mW)

      Unit price (USD)

      PIC (PIC16F1947) [19]







      ARM Cortex M3 (LPC1316FBD48) [20]







      AVR (ATMEGA644P) [18]







      XMEGA-A1 (ATXMEGA128A1) [18]







      acan be increased using PLL up to 72 MHz.

      Graphical LCD with touch screen

      To enable RTV of images, graphs, charts, texts, etc., during data logging, a 2.4″ graphical LCD [21] capable of displaying 320 × 240 pixels (QVGA) using 262,144 colors is chosen. The display also contains resistive touch area, enabling advanced and interactive user interface. The LCD connects with the MCU using hardware USART and it receives command from the MCU at a baud rate of 2 Mbps.

      Data storage device

      In Table 2, the comparisons of different permanent memory storage device in a single chip are shown [18]. Parallel EEPROMs need significant number of I/O lines to interface with MCU. Serial EEPROMs need relatively lesser I/O lines; however, their memory capacity is low and cascading several EEPROMs for increasing capacity, needs significant area, and more I/O lines. Micro SD card [22] seems to be the best choice as it has high memory capacity and needs only few I/O lines. Moreover, its defect and error management unit promises reliable data read/write. In the data logger design, two 2-GB SD card are connected with the MCU using hardware SPI at a 16-MHz clock speed. Note that, several SD cards may be connected as shown in Figure 4 and the storage capacity can be increased significantly. When one SD becomes full, data are written in another SD card automatically, and thus data logging can continue without the interruption of replacing SD card. Moreover, data can be transferred from SD card to PC using SD/MMC card reader at high speed such as 25 MB/s.
      Table 2

      Comparison of different permanent memory storage device



      Micro SD





      3 WIRE


      512 kB

      64 kB

      64 kB

      2 kB

      2 GBa

      Clock (MHz)






      Pins required






      Error correction






      aMaximum capacity for FAT16 file-system for a single SD.

      bIn standard SPI mode.
      Figure 4

      SD card connection with MCU by SPI.

      Wireless transceiver

      The characteristics of several wireless transceiver units are shown in Table 3. The major challenge of any wireless link is the data corruption in the transmission channel. Nordic transceiver [23] contains cyclic redundancy check (CRC)-based error detection and retry with auto acknowledgement (i.e., resend data packet until success) feature which makes the link promisingly reliable, though several retry may decrease the overall data transmission rate in a noisy environment [15]. We selected Nordic for our application and it is connected with the MCU using hardware SPI at 8 MHz speed.
      Table 3

      Comparison of different wireless transceivers


      Zarlink [[24]]

      Linx [[25]]

      Micrel [[26]]

      Zigbee [[27]]

      Nordic [[23]]

      Frequency band

      402 MHz

      433 MHz

      915 MHz

      2.4 GHz

      2.4 GHz

      Data rate

      800 kbps

      10 kbps

      115 kbps

      250 kbps

      2 Mbps

      Retry and auto ack.






      TX current (mA)






      RX current (mA)







      A Bluetooth transceiver [28] is also connected with the MCU using hardware USART at 230-kbps baud. Data transmitted from wireless body sensor can be captured either by Nordic or by Bluetooth in the data logger and then can be uploaded wirelessly to personal computer or Smartphone using Bluetooth.

      USB interface

      The design also contains an USB interface (as shown in Figure 5) that has 1-Mbps data rate to connect with PC using wired link. This wired interface can optionally be used to transfer data to workstation PC after data logging.
      Figure 5

      USB interface to PC.

      Analog interface

      Analog data can also be taken in the data logger using the wired analog interface. The analog interface consists of multiplexed eight programmable ADC channels, eight analog comparators, and two digital-to-analog converter channels of the microcontroller. Analog data such as body temperature, blood pressure can be taken using the ADC channels and then the data can be saved in SD card and its real-time graphical plot can be displayed on LCD.

      Power supply

      As the power source of the data logger, three 3.7V polymer lithium-ion battery, each having 2000-mAh rating are used in parallel, thus making total battery rating of 6000-mAh. The design also contains a 200-mA having 3.3–V output voltage boost converter [29] and an under voltage protection of 2.6 V. A 500-mA constant current battery charging circuit [30] using PC’s USB port is also included in the design so that recharging can be done without removing the batteries from the hardware. To indicate and monitor the charging level, the battery voltage is sampled using a potentiometer and fed to an ADC channel of the microcontroller.

      Other peripherals

      To interact with the user, the design contains four push button switches. The button press is signaled to the MCU as interrupt. A buzzer is included in the design to generate small beep sounds.

      Driver firmware and disk operating system (DOS)

      The driver layer consists of low-level firmware for accessing different hardware peripherals. They are briefly described below.

      Graphical LCD and touch screen

      The driver for graphical LCD contains functions for initializing the LCD, drawing pixels at any position by providing the co-ordinate and color information, setting background color and brightness, taking the LCD in low-power sleep and wake-up modes, etc. The touch screen driver functions provide the co-ordinate when a touch is made on the screen.


      When any of the four keys (Up, Down, Enter, and Escape) is pressed, the program jumps to its corresponding interrupt routine and sets a flag for that particular key. By executing a get_key () function, the last key pressed is detected by reading the flags.

      Wireless RF transceiver

      It contains functions for reading and writing data to the configuration registers of Nordic RF module using SPI, setting the RF module as transmitter or receiver, flashing, and checking the status of internal Fast in, Fast out (FIFO) buffers, sending and receiving data packets to/from other RF module, taking the module to power down and up mode, etc.


      These functions initialize the Bluetooth device as slave, connect with nearby Bluetooth master devices (such as Smartphone or PC) when request is made, then send and receive data to/from master Bluetooth device using USART. It also contains functions to take the module in low-power sleep and wake-up modes.


      To generate a “beep” sound, square pulses of 1 kHz are sent for the duration of 500 ms to the buzzer.

      SD card and DOS

      It contains functions for checking whether any SD card is present in the slot, selecting and initializing the SD card, checking the available memory space, etc. A DOS for embedded system [31] is implemented which handles file operations. Using DOS, data files can be created, read, written, and deleted. The DOS implements FAT16 file system and the maximum writing speed in SD card is found to be 115 kB/s when the MCU is running at 32 MHz.

      USB interface

      This driver sends and receives data to/from PC. Data are transferred from the MCU using USART protocol and through an RS232-USB converter chip, data are packed according to USB protocol to transmit to PC through USB port.

      Analog interface

      It configures the ADC resolutions (such as 8, 10, 12 bit), reference voltage, channel gain, etc. It provides functions using which the corresponding digital data of an analog channel can be read and processed. It also contains functions to check battery voltages in the Power Supply module.

      Application firmware

      This layer contains the firmware designed for a specific data logging application. The proposed data logger is generic that encompasses many different medical applications such as ECG, heartbeat, capsule endoscopy, blood pressure, etc. In this study, we have implemented the firmware for capsule endoscopy application [6].

      User interface

      In order to set different settings such as image size, imaging mode, enable/disable real-time view, etc., a menu-based graphical user interface is designed in the data logger as shown in Figure 6. User can use either four keys (Up, Down, Enter, and Escape) or touch to select different menu options. Additional features may easily be added to the interface if needed.
      Figure 6

      Menu tree of the data logger.

      Data logging

      In order to receive data from the bio-sensor (i.e., capsule in this case study), a command is sent wirelessly to the capsule from the data logger containing information of required image size and imaging mode. After receiving command, the capsule starts to send the data packets of an image frame in compressed from. The data logger reads the packets and stores them in SD card. A timer is also used to add time stamp for each image frame. The end of a frame is detected by a pattern of consecutive four zero bytes. The overall data logging procedure is shown in Figure 7.
      Figure 7

      Flowchart of the data logging procedure for capsule endoscopy.

      Image decoding algorithm

      In capsule endoscopy, image data are transmitted wirelessly from the ingested capsule in compressed form. Our proposed compression algorithm consists of a novel color space, YEF [32], which is designed by analyzing the unique properties of endoscopic images for better compression. After converting RGB pixels to YEF color space, the compressor takes the difference of consecutive pixels (left pixel prediction) and then encodes the differences in variable length coding such as in Golomb-rice code. Based on the nature of endoscopic images, several sub-sampling schemes (such as YEF812) on the chrominance (E and F) components are applied. YEF812 sub-sampling means Y is not sub-sampled, E is sub-sampled after every 8 pixels, and V is sub-sampled after every 4 pixels. The sub-sampling is performed in horizontal direction only. A customized corner clipping scheme is also implemented to remove uninteresting corner area of the image to increase CR [33]. The proposed algorithm works in raster scan fashion and can directly be interfaced with commercial image sensors, eliminating the need of buffer memory. The compressor has an average CR of 80.4% and reconstructed image quality have peak signal-to-noise ratio (PSNR) index of about 43 dB.

      In the data logger, the decoder for the above discussed compression algorithm is implemented for RTV of images. The overall image decoding algorithm is shown in Figure 8.
      Figure 8

      Block diagram of the image decoding algorithm.

      In the compressed bit stream, the first pixel component is stored in raw 8-bit format. This is read in X, where X is the actual pixel value. In YEF color space, X corresponds to Y, E, and F components. Xp is the next predicted pixel value. Initially
      Xp = X
      Next we define
      I = 2 8 = 256
      M = 2 k ,
      where k is Golomb-rice code parameter. The maximum length of Golomb-rice code (glimit) is chosen as 32. The pseudo code for Golomb-rice code decoder is shown in Figure 9.
      Figure 9

      Pseudo code for Golomb-rice decoder.

      The decoded m_dx is then inversely mapped to signed integer as shown in the pseudo code in Figure 10.
      Figure 10

      Pseudo code for inverse mapping.

      The differential pulse coded modulation decoder then calculates the next actual pixel value using (5) and sets the prediction for next pixel using (2).
      X = Xp + dX
      After the actual component values of a pixel are calculated, they are converted to RGB color space using (6).
      R G B = 1 3.33 2.67 1 2 0 1 0.67 2.67 Y E 128 F 128
      The R, G, B pixels are sent to graphical LCD for displaying the image frame. In order to display VGA images in QVGA size show, the VGA image is sub-sampled by 4. In Figure 11, the original and reconstructed images of an endoscopic image are shown.
      Figure 11

      Comparison between original and reconstructed image (a) Original image. (b) Reconstructed image (PSNR is 43 dB).

      Data uploading

      After data logging, data can be uploaded to PC or Smartphone using any of the following three methods: (1) by removing the SD cards from data logger, (2) using USB interface, and/or (3) using wireless Bluetooth link. When using USB or Bluetooth link, a file transfer protocol is implemented which sends at first the filename, then the file size, and then its data bytes. A PC software is developed to receive the data from the data logger by USB or by Bluetooth. After receiving compressed data, the PC software can decode and display the images as video at any given FPS.


      Specification of data logger prototype

      The proposed data logger for capsule endoscopy application is prototyped in our laboratory as shown in Figure 12. The size of the prototype is 10 × 10 × 2 cm. The weight of the PCB is 114 g; each battery weighs 37 g, making the total weight of the prototype 151 g with one battery. With three batteries, the total weight is 114 + (3 × 37) = 225 g. Note that, for capsule endoscopy application, minimum 10-h battery life is required. If we use one battery instead of three batteries then the hardware can run for 35.3/3 = 11.8 h, which meets the design requirement for capsule endoscopy application. As the design of the proposed data logger is general, three batteries are used to meet other applications which may require more data logging time.
      Figure 12

      Photograph of the prototype. (a) Top view (compared with a Canadian $2 coin). (b) Bottom view.

      Experimental results for RF channel selection

      We have conducted experiments to observe the interference of other frequencies (such as Wi-Fi, Smartphone, medical instruments, etc.) in both hospital (Royal University Hospital, Saskatoon, SK, Canada) and home environment [15] on the Nordic transceiver in its different frequency channels. Several experiments showed that using duck antenna [34] instead of chip antenna improves the RF transmission quality. In Figure 13, the number of retry required by the transceiver to send 100 data packets (each packet contains 32 bytes) in different frequency channels in several environments using duck antenna is shown. As the data logger is wearable, the distance between the sensor and the logger should be less than 1 m (taking a conservative approach).
      Figure 13

      Number of retry required in different frequency channels; (a) in home environment, (b) in home environment near Smartphone in use, (c) in hospital environment near medical imaging department, (d) in hospital environment near cancer department.

      From Figure 13, we see that several retries are required from 2.4 to 2.48 GHz channels due to interference in different environments. So, we have decided to operate the transceiver in a clear channel at 2.5 GHz which will cause minimum number of retries during data transmission. Note that, the Bluetooth device will not have any interference effect on Nordic transceiver as they work in a mutually exclusive way.

      It is possible to select the best channel dynamically during data logging. The procedure is as follows.
      1. 1.

        The data logger will go to channel selection mode after a configurable time (for instance, every after 30 min) or by user at anytime from selecting a menu option.

      2. 2.

        The data logger will send a command to the bio-sensor to set its transceiver at the first channel and the data logger will also set its transceiver to the first channel. Then the data logger will send some data-packets to the bio-sensor and log the number of retry required for that channel. This step will be done for all the available channels (in Nordic transceiver, a total of 126 channels starting from 2.4 to 2.526 GHz are available).

      3. 3.

        Then the channel which has minimum retries will be selected and the data logger will send a command containing the channel number to the bio-sensor so that both data logger and bio-sensor communicates at the same channel.


      Experimental results simulating capsule endoscopy scenario

      An MCU-based capsule emulator hardware as shown in Figure 14 is developed for testing the data logger prototype. The compression algorithm proposed in [32, 33] is implemented in a PC software and compressed bit-stream data for several endoscopic images are generated using the software. Then the compressed bit-stream data are downloaded in the program-memory of the MCU of the capsule emulator. When the capsule emulator receives a command from the data logger through the RF interface, it starts to send compressed image data to the data logger wirelessly.
      Figure 14

      Block diagram of capsule emulator.

      In order to test the data logger for a capsule endoscopy scenario, the capsule emulator hardware is inserted inside a turkey and the data logger is placed 0.3–m away from the capsule as shown in Figure 15. The data logger received images wirelessly through the turkey’s skin and flesh successfully from the capsule. As the data logger is wearable and it is generally worn at one side of the belly, the distance between a swallowed capsule and data logger will be near 0.3–m for human endoscopy. The data logger is also placed about 1 m apart from the inserted capsule and images transmitted successfully.
      Figure 15

      Experimental setup: capsule emulator is placed inside a turkey and the data logger is placed outside.

      Experiment results for multiple body sensors

      In order to test the wired analog interfaces of the data logger prototype, two temperature sensors [35] are connected with two analog ADC channels. The temperature sensor gives analog voltage output proportional to its surface temperature (0.01 V/°C). The sensors are placed on two places of a human hand as shown in Figure 16. The data logger is programmed to sample data at 10 Hz. It converts the sampled analog data to digital, stores them in SD card along with time stamp, and plots the data on graphical LCD for real-time display as shown in Figure 16. The logged data can be transferred to PC or Smartphone and further analysis can be done. By using the analog channels, blood pressure, ECG, heartbeat signals can also be logged and displayed.
      Figure 16

      Skin temperature logging and display: (a) real-time display on LCD; (b) logged data plotted in MATLAB.

      Power consumption

      The power consumption of the data logger in different modes is shown in Table 4. When RTV is disabled, the graphical LCD is taken to sleep mode to save power. In Figure 17, the percentage power consumption of different hardware components during data logging (using Nordic RF link, in RTV enabled mode) is shown. We see that the LCD consumes the majority of power (54%) if the RTV is enabled. It should be noted that the RTV mode is not a normal mode of operation, rather a special feature that a physician may use if desired. After the data logging is completed, it can be transferred to PC by removing the SD card, which costs no power for the data logger. When transferring data using Bluetooth, the LCD and Nordic RF are taken to sleep mode to save power. During data transfer by USB interface, the Bluetooth is also taken to sleep mode.
      Table 4

      Power consumption in different modes


      Current (mA)

      Power (mW) @ 3.3 V

      Display menu



      Data logging in SD card


       RTV enabled



       RTV disabled



      Data transfer to PC


       Using SD card reader






       USB interface


      Figure 17

      Percentage power consumption of different hardware components.

      Comparison with other works

      The overall specification of the designed data logger and its comparison with other works are shown in Table 5. Comparing with other works on data loggers in the literature, the proposed data logger has high-speed wireless connectivity including Bluetooth, contains graphical LCD for real-time data viewing, and touch screen. The storage space is sufficient for many other medical applications; moreover, it can be increased easily by connecting more SD cards as shown in Figure 4 or implementing FAT32 file system in the firmware which can support higher capacity SD card (8 GB or higher) than FAT16. The writing speed and RF bandwidth of the data logger is sufficiently high to capture and store data at high sampling rate. Thus, the proposed data logger fulfills all the design requirements as discussed in Design requirements section for capsule endoscopy application. The data logger is designed for capturing images and images need more RF bandwidth, disk space, writing speed, etc., than recording other physiological signals such as heart beat, blood pressure, temperature, etc. So, the proposed data logger can be used efficiently in other medical applications.
      Table 5

      Comparison with other data loggers


      Memory capacity

      Sampling rate (writings speed)


      Analog interface

      Graphical LCD

      Touch input

      Battery life (hour)


      16 MB

      13.2 kHz







      20 MB

      200 Hz






      500 Hz







      60 Hz

      250 kbps






      512 MB

      33 kS/s







      512 kB







      512 MB






      This study

      4 GBb

      192 k pixel/sc (115 kbps)

      2 Mbps link and Bluetooth





      anot battery operated, bexpandable, cfor 80% CR.


      Wireless data transmission

      The medical implantable communication service (MICS) compatible RF transceiver, which works at 402–405 MHz frequency, is the most suitable for transmitting data through the human body [36]. However, the MICS RF transceiver vendor, Zarlink [24], sells a low data rate (effective data rate around 500 kpbs [37]) transceiver (ZL70102) which is not sufficient even for 2 FPS capsule endoscopy application. Zarlink has a custom transceiver (ZL70081) having a data rate of 2.7 Mbps which is not available for public purchase. So, we used the RF transceiver by Nordic [23], which works at 2.4 GHz frequency band and having a data rate of 2 Mbps. However, the effective data rate with minimum header information is 1.68 Mbps. The studies in [37, 38] show that 2.4 GHz transceivers, such as Nordic, can effectively be used to get data wirelessly through animal body.

      In this design, the Nordic transceiver was configured in auto acknowledgement mode. In auto acknowledge mode, after receiving a data packet, the receiver checks the CRC bits and detects whether there was any error during the transmission of the packet. If there was any error, then it requests the transmitter to resend the data packet again. This process goes on until the packet is transmitted successfully. So, in auto acknowledgement mode, no data loss happens, though the number of retries will decrease the overall data rate or application throughput. If the receiver is unable to detect error using CRC, then depending upon which bits get corrupted, the reconstructed image will have different distortions. The image compression algorithm [32, 33] used here is line-based differential coding (i.e., works row-by-row in raster scan fashion). In some cases, one row (or part of a row) of the image pixels may get corrupted if undetectable errors occurs in data packets. In worst case, the entire image frame may get corrupted.

      Commercial capsule endoscopy products [6] such as PillCam SB, EndoCapsule, and MiroCam send images of size 256 × 256, 256 × 256, and 320 × 320, respectively. VGA (640 × 480) images are difficult to sent at 2 FPS because it requires very high data rate custom design RF transmitter. Though, some research works are available in the literature [39, 40] on high data rate (as high as 15 Mbps) transmitter for capsule endoscopy, however, they are not commercially available yet. So, the bottleneck of sending VGA images at 2 FPS is the RF transmitter. However, VGA images can be sent at lower FPS using the limited available bandwidth of the commercially available RF transmitters. In order to send VGA color images at 1 FPS, having 80% CR for 10 h, the memory space, the RF data rate, and the writing speed should be at least 6.2 GB, 1440 kbps, and 180 kB/s, respectively. To increase the size of memory capacity, the number of SD cards as shown in Figure 4 can be increased to more than 2. The MISO, MOSI, and SCK pins of the additional SD cards will be connected directly with the MCU’s MISO, MOSI, and SCK pins and extra SS pin from the MCU needs to connect with the additional SD cards SS pins. Moreover, memory capacity can be also increased without changing any hardware design. Secure Digital High Capacity (SDHC) cards can be used instead of SD cards which have a capacity of 32 GB and have higher writing speed than SD cards [41]. In order to read/write data in SDHC, FAT32 file system needs to be implemented in the firmware instead of FAT16.

      Cost of developing the data logger prototype

      The engineering cost of the proposed data logger is approximately around 260 h. The task list, tentative time required for each task, qualification, and number of personnel are shown in Table 6. This approach can easily be adapted by other researchers interested in similar development. The manufacturing cost of the data logger is shown in Table 7. It should be noted that the cost of programmer module is one-time. For bulk manufacturing, the cost will significantly be lower.
      Table 6

      Engineering cost of the data logger


      Time required (hours)

      Personnel qualification

      Number of personnel

      Requirement analysis


      Researcher (graduate student)


      Specification and system design


      Hardware/software partitioning


      Embedded system engineer (or similar)


      Purchasing components, tools, and compilers


      Hardware design


      Firmware design


      Prototyping, debugging, and testing


      PCB design and testing




      Table 7

      Manufacturing cost of the data logger


      Price (USD)

      Hardware components (LCD, MCU, RF unit, Bluetooth unit, misc)


      Programmer unit (one-time cost)


      PCB fabrication




      Future works

      A small size FPGA-based capsule prototype is now under development where a novel image compression algorithm proposed in [32, 33] is implemented. After the final capsule prototype is developed, it will be inserted in pigs intestine [42] due to its relatively similar gastrointestinal functions in comparison to human and live images will be captured for more rigorous animal testing.

      Testing the data logger with capsule endoscopy prototype in several human patients faces several challenges. A number of capsule prototypes need to be manufactured which requires significant amount of time, money, and human resource. Then the permission from Food and Drug Administration [43] needs to be taken for swallowing the prototype capsules in human. Moreover, it requires approval from hospital, managing a number of patients having gastrointestinal diseases, and involvement of gastroenterologist to evaluate the performance [44] and measuring the accuracy of their decision (fraction of correct decisions, false positives, false negatives, etc.) using statistical tools such as receiver operating characteristics analysis [45]. These tasks are beyond the scope of the article and left for future exploration.


      In this article, the design of a microcontroller-based portable data logger is presented that is targeted for general medical imaging and data collection application. It has high data rate wireless connectivity including Bluetooth, graphical display for real-time data viewing with state-of-the-art touch screen technology. The data are logged in micro SD cards and can be transferred to PC or Smartphone using card reader, USB interface, or Bluetooth wireless link. The features of the prototype are demonstrated for a WCE and skin temperature logging application.



      This study was supported by the Natural Science and Engineering Research Council of Canada (NSERC) and the Canada Foundation for Innovation (CFI). The authors would like to give thanks to Mohammad Shamim Imtiaz for helping in collecting data from hospital environment and to Serge Nazerenko for his technical assistance in making the prototype.

      Authors’ Affiliations

      Department of Electrical and Computer Engineering, University of Saskatchewan


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      © Khan and Wahid; licensee Springer. 2012

      This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​2.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.